首页 Translate Bio Inc.(usTBIO)-基本信息

Translate Bio Inc.(usTBIO)-基本信息

日报更新时间:

周报更新时间:04-18 04:06

行情信息

今开价:19.56

最高价:20.22

成交量:384577.0

昨收价:19.78

最低价:19.009

最新价:20.22

行情图标
概要信息

英文名称:Translate Bio Inc.


简介:Translate Bio, Inc.是一家特拉华州的公司,于2016年11月10日成立


电话:1-617-9457361


最新量化综合结论
百科信息
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  • 百科
  • 员工交易记录
  • 持股信息

Translate Bio, Inc.使用公司专有的mRNA治疗平台(MRT),创建具有编码功能蛋白质的mRNA,该mRNA被递送到靶细胞,在细胞自身的机制下识别并翻译它,恢复或增强蛋白质功能来治疗或预防疾病。mRNA在蛋白质合成中起着核心作用,蛋白质是实现基本细胞功能所必需的。mRNA将DNA中编码的遗传信息转录成细胞用于产生蛋白质的指引。Translate Bio公司的mRNA通过专有的无细胞酶催化过程制造,使用与人体内天然mRNA相同的结构成分。公司通过将其生物合成mRNA包装成专有的基于脂质的纳米颗粒(LNP)递送载体来配制候选产品,所述载体经优化用于分配至特定组织。Translate Bio公司的MRT平台在过去十年持续在开发,最初在Shire Human Genetic Therapies, Inc.并自2016年起在Translate Bio内部进行开发。随着MRT的科学创始人现在成为Translate Bio公司领导团队的一员,公司最初建立在Shire的开创性工作和投资基础,现在得以推进为患者带来转化性mRNA疗法。Translate Bio相信,公司的MRT平台适用于由蛋白质产出不足或蛋白质病变(包括影响肺,肝,眼,中枢神经系统,淋巴系统和循环系统的疾病)所导致的各种疾病。Translate Bio的两项主要计划正在开发中,用于治疗囊性纤维化(CF)和鸟氨酸转氨甲酰酶(OTC)缺乏症。Translate Bio的候选产品由两个主要组成部分组成:蛋白质编码mRNA和递送载体。一旦公司建立了对目标组织的递送能力,其就可以设计出仅在mRNA序列上有所不同的新候选产品,公司期望这些候选产品能够快速确定目标并完成递送。Translate Bio的MRT平台在开发更多候选产品时具有灵活性和可扩展性。公司设计其mRNA序列以提高稳定性,并提供所需蛋白质的最佳表达。Translate Bio最初专注于开发治疗肺癌和肝脏疾病的候选产品。 Translate Bio相信其平台有可能应用于各种疾病和靶组织。 在公司的临床前研究中,观察到靶向递送到眼睛,中枢神经系统或中枢神经系统,淋巴系统和循环系统,以及其平台能够产生抗体的能力。 此外,与前几代mRNA技术以及竞争方法相比,公司观察到mRNA效能和递送的显着改善。

交易日期 交易人 职位 类型 交易份额 价格
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 461072 --
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 1789930 1.00
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 344822 --
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 922141 --
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 894965 1.00
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 577319 --
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 1472636 1.00
2016-01-05 Kirk (Randal J) Beneficial Owner of More than 10% Class Buy 317294 1.00

机构持股
持有者 持有份额 持股比例 份额变化 变化率 报告日期
Brookside Capital Management LLC 416670 0.82% -- -- 2019-03-31
RTW INVESTMENTS, LLC 1352970 2.66% 1352970 -- 2019-03-31
Fidelity SelectCo, LLC 1522497 2.98% -417685 -21.53% 2019-07-31
BlackRock Fund Advisors 1561229 3.06% -42421 -2.65% 2019-07-31
BlackRock Inc 1965575 3.86% 983170 100.08% 2019-03-31
Omega Fund Management LLC 4875206 9.58% 2437603 100.00% 2019-03-31
Baupost Group LLC 6491298 12.75% 11 -- 2019-03-31
Fidelity Management and Research Company 6771428 13.30% 115 -- 2019-03-31
FMR Inc 6771428 13.30% 115 -- 2019-03-31
Fidelity Management & Research Company 1206453 2.37% 204205 20.37% 2019-07-31
Federated Investors Inc 1130000 2.22% -- -- 2019-03-31
Federated Equity Mgmt Co. Of Penn 1130000 2.22% -- -- 2019-07-31
Perceptive Advisors LLC 435000 0.85% -- -- 2019-03-31
Cormorant Asset Management, LLC 454549 0.89% -1 -- 2019-03-31
Northern Trust Investments Inc 548235 1.07% 36571 7.15% 2019-07-31
Artal Group S A 600000 1.18% -- -- 2019-03-31
Fidelity Management Trust Co 836866 1.64% -- -- 2019-07-31
Vanguard Group Inc 844577 1.66% 443083 110.36% 2019-03-31
Vanguard Investments Australia Ltd 885443 1.74% 208470 30.79% 2019-07-31
Rock Springs Capital Management LP 1009179 1.98% -- -- 2019-03-31
BlackRock Asset Management Canada Ltd 795250 1.56% 1113 0.14% 2019-05-31
Farallon Capital Management, L.L.C. 500000 1.10% 50000 11.11% 2018-12-31
Sphera Funds Management Ltd. 309400 0.68% 32761 11.84% 2018-12-31
ArrowMark Colorado Holdings, LLC (ArrowMark Partners) 367744 0.81% -321950 -46.68% 2018-09-30
Wells Fargo & Co 273313 0.61% 163313 148.47% 2018-09-30
Dafna Capital Management LLC 151739 0.34% 131739 658.69% 2018-09-30
Citigroup Inc 571000 1.26% 571000 -- 2018-06-30
Federated Global Inv Mgmt Corp 710195 1.57% 710195 -- 2018-06-30
Deerfield Management Co 650000 1.44% 650000 -- 2018-06-30
Wells Fargo Funds Management LLC 192255 0.43% 127 0.07% 2018-10-31
UBS Asset Mgmt Americas Inc 41400 0.09% 41400 -- 2018-06-30
Key Square Capital Management LLC 55000 0.12% 55000 -- 2018-06-30
Alyeska Investment Group, L.P. 60000 0.13% 60000 -- 2018-06-30
Goldman, Sachs & Co. 93500 0.21% 93500 -- 2018-06-30
Millennium Management LLC 109651 0.24% 109651 -- 2018-06-30
Wells Capital Management Inc. 110000 0.25% 110000 -- 2018-06-30
Luminus Management LLC 152163 0.34% 152163 -- 2018-06-30
Arrowpoint Asset Management, LLC 689694 1.54% 689694 -- 2018-06-30
Pentwater Capital Management LP 30000 0.07% 30000 -- 2018-06-30
Schonfeld Strategic Advisors LLC 20000 0.04% 20000 -- 2018-06-30
BlackRock Advisors LLC 25663 0.06% -5647 -18.04% 2018-07-31
AST Investment Services Inc 20100 0.04% 20100 -- 2018-06-30
Columbia Mangmt Investment Advisers, LLC 18196 0.04% -100 -0.55% 2018-07-31
SPGP 12166 0.03% 12166 -- 2018-06-30
AQR Capital Management LLC 1000 -- 1000 -- 2018-06-30
GlaxoSmithKline PLC 269280 -- 269280 -- 2018-06-27
Guggenheim Capital LLC 24814 0.10% 24814 -- 2016-09-30
Citadel Advisors Llc 44814 0.19% 44814 -- 2016-09-30
Panagora Asset Management Inc 87358 0.35% 87358 -- 2016-09-30
CAMBRIDGE Invest RESEARCH ADVISORS, INC. 113900 0.47% -- -- 2016-09-30
White Pine Capital LLC 168579 0.71% -50000 -22.88% 2016-09-30
Renaissance Technologies Corp 219900 0.91% 111000 101.93% 2016-09-30
Third Security, LLC 7550669 31.06% -- -- 2016-09-30
TWO SIGMA SECURITIES, LLC 17252 0.07% 17252 -- 2016-09-30
Susquehanna Financial Group, LLLP 16795 0.07% 16795 -- 2016-09-30
Creative Planning Inc 512 -- -- -- 2016-09-30
Merrill Lynch & Co Inc 1617 0.01% 1115 222.11% 2016-09-30
Advisory Services Network, LLC 5378 0.02% 3404 172.44% 2016-09-30
Northern Trust Investments N A 11055 0.04% -- -- 2016-09-30
KCG AMERICAS LLC 11530 0.05% -7287 -38.73% 2016-09-30
Wells Fargo Advisors, LLC 12747 0.05% -166 -1.29% 2016-09-30
Geode Capital Management, LLC 13347 0.06% -- -- 2016-09-30
Randal J. Kirk 770490 4.00% 1356062 0.10% 1999-11-30
Dolphin Offshore Partners, L.P. 864098 4.00% 1520812 0.10% 1999-11-30
Orin Hirschman 948200 4.00% 1668832 0.10% 1999-11-30
Kevin Douglas 1046860 4.00% 1842474 0.10% 1999-11-30
共同基金持股
持有者 持有份额 持股比例 份额变化 变化率 报告日期
Schwab Small Cap Index Fund 61656 0.12% 1869 3.13% 2019-06-30
Federated Kaufmann Small Cap Fund 1130000 2.22% -- -- 2019-03-31
Vanguard Total Stock Market Index Fund 885443 1.74% 208470 30.79% 2019-06-30
Fidelity Growth Company Commingled Pool 836866 1.64% -- -- 2019-06-30
iShares Russell 2000 ETF 656054 1.29% 1287 0.20% 2019-07-30
iShares Nasdaq Biotechnology ETF 503338 0.99% 6498 1.31% 2019-07-30
Vanguard Extended Market Index Fund 410965 0.81% 123101 42.76% 2019-06-30
iShares Russell 2000 Growth ETF 266243 0.52% -- -- 2019-07-30
State Street Russell Small Cap 133898 0.26% -- -- 2019-06-30
Fidelity 117359 0.23% 82307 234.81% 2019-04-30
NT R2000 Index Fund - NL 107723 0.21% -7805 -6.76% 2019-06-30
NT R2000 Growth Index Fund - Non-Lending 101422 0.20% -5521 -5.16% 2019-06-30
Northern Trust Russell 2000 Index DC NL 81780 0.16% -6399 -7.26% 2019-06-30
Invesco DWA SmallCap Momentum ETF 78719 0.15% -- -- 2019-07-31
NT R2000 Growth Index Fund - Lending 74482 0.15% 1290 1.76% 2019-06-30
iShares Micro-Cap ETF 74444 0.15% -- -- 2019-07-30
MEDICAL BioHealth 115488 0.23% -- -- 2019-03-31
Russell 2000 Index Non-Lendable Fund E 61697 0.12% 44342 255.50% 2019-03-31
iShares US Small Cap ETF (CAD-Hedged) 594866 1.17% -999 -0.17% 2019-05-30
State Street Russell Small/Mid Cap 41500 0.09% 3900 10.37% 2019-02-28
BlackRock Russell 2000 45224 0.10% 32547 256.74% 2019-03-31
iShares Russell 2000 Value ETF 46036 0.10% -- -- 2019-03-29
iShares Core S&P Total US Stock Mkt ETF 47257 0.10% 48 0.10% 2019-03-29
APO Medical Opportunities 57412 0.13% -- -- 2019-02-28
BSF Global Event Driven Fund 57428 0.13% -- -- 2018-08-31
AXA 2000 Managed Volatility Portfolio 18651 0.04% 7038 60.60% 2018-12-31
SPDR 18306 0.04% 80 0.44% 2019-02-28
RIM Global Bioscience 16136 0.04% 10136 168.93% 2019-01-31
ProShares Ultra Nasdaq Biotechnology 18277 0.04% 5577 43.91% 2019-02-28
apo Medical Opportunities Institutionell 16000 0.04% 4500 39.13% 2019-01-31
The Vanguard - Russell 2000 Grwth Idx CF 15018 0.03% -- -- 2019-01-31
Fidelity Advisor 417685 0.93% 417685 -- 2018-12-31
Vanguard Russell 2000 Index Fund 13266 0.03% 2788 26.61% 2018-12-31
FCP MEDICAL BioHealth-Trends 74000 0.16% 37000 100.00% 2018-10-31
VP Partners Small Cap Growth Fund 20874 0.05% -1192 -5.40% 2018-11-30
Wells Fargo Emerging Growth Fund 24638 0.05% -51211 -67.52% 2018-11-30
Meridian Small Cap Growth Fund 184650 0.41% -175466 -48.72% 2018-09-30
Wells Fargo VT Small Cap Growth Fund 30113 0.07% -20955 -41.03% 2018-10-31
TIAA-CREF Small-Cap Blend 12634 0.03% -- -- 2018-10-31
BlackRock Event Driven Equity Fund 25663 0.06% -- -- 2018-08-31
SEI Small Cap Growth (SIMT) Fund 15774 0.03% -10291 -39.48% 2018-10-31
AST Small-Cap Growth Portfolio 20100 0.04% -- -- 2018-09-30
Vanguard Total Stock Mkt Idx 19742 0.04% 19742 -- 2018-07-31
AST Small-Cap Growth 20100 0.04% -- -- 2018-07-31
BlackRock Event Driven Equity Inv A 25663 0.06% -5647 -18.04% 2018-07-31
Wells Fargo VT Small Cap Growth 2 28868 0.06% 8256 40.05% 2018-07-31
Wells Fargo Emerging Growth Admin 73717 0.16% 21775 41.92% 2018-07-31
Meridian Small Cap Growth Investor 360116 0.80% 360116 -- 2018-06-30
Federated Kaufmann Small Cap A 710195 1.59% 710195 -- 2018-06-30
SEI Small Cap II A (SIIT) 20256 0.04% -- -- 2018-08-31
VP Partners Small Cap Growth 2 18196 0.04% -100 -0.55% 2018-07-31
SEI Small Cap Growth A (SIMT) 28923 0.06% -- -- 2018-08-31
Vanguard Balanced Index Inv 683 -- 683 -- 2018-07-31
Vanguard Russell 2000 ETF 736 -- 736 -- 2018-07-31
The Vanguard Russell 2000 Growth Index 946 -- 946 -- 2018-07-31
AQR Diversified Arbitrage I 1000 -- 1000 -- 2018-06-30
Vanguard Instl Ttl Stk Mkt Idx InstlPls 1314 -- 1314 -- 2018-07-31
UBS US Small Cap Growth P 5000 0.01% 5000 -- 2018-06-30
Vanguard Extended Market Idx Inv 10545 0.02% 10545 -- 2018-07-31
Catalyst IPOx Allocation A 428 -- 428 -- 2018-06-30
Wells Fargo Diversified Equity Admin 378 -- 107 39.48% 2018-07-31
Vanguard Russell 2000 Growth ETF 333 -- 333 -- 2018-07-31
Wells Fargo Growth Balanced Admin 224 -- 224 -- 2018-06-30
Wells Fargo Moderate Balanced Admin 90 -- 90 -- 2018-06-30
The Vanguard Total Stock Market Index 7200 0.03% -- -- 2016-12-31
iShares Core S&P Total US Stock Mkt 4548 0.02% -- -- 2017-02-07
Fidelity Spartan 13347 0.05% -- -- 2016-12-31
Wilshire Micro-Cap ETF 24814 0.10% -- -- 2017-02-08
AXA/Lord Abbett Micro Cap Portfolio 2034 -- -- -- 2015-09-30
The Vanguard - Total Stk Mkt Idx Trust. CF 7200 -- -- -- 2015-10-31
Fidelity Spartan® Extended Mkt Indx Fd 13347 0.10% -- -- 2015-09-30

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