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中文名称：彪马生物技术
英文名称：Puma Biotechnology
简介：Puma Biotechnology, Inc.是于2007年4月27日成立的特拉华州公司，该公司是一家集开发阶段的生物制药公司，收购并开发创新的产品，致力于各种形式的癌症治疗
电话：1-424-2486500
目前，Puma Biotechnology目前主要有3个候选药物： PB272 neratinib（口服），用于治疗早期乳腺癌，转移性乳腺癌，非小细胞肺癌，HER2突变阳性实体瘤和HER2突变的非扩增乳腺癌； PB272 neratinib（静脉注射）； 公司还开发了PB357，这是一种口服药物，是一种不可逆的酪氨酸激酶抑制剂，通过表皮生长因子受体HER1，HER2和HER4阻断信号转导。彪马生物技术公司与辉瑞公司签订了许可协议，用于开发，生产和商业化PB272奈拉替尼（口服），PB272奈拉替尼（静脉注射），PB357和某些相关化合物。2017年7月，Puma Biotechnology旗下的试验性乳腺癌治疗药物获得了FDA批准，该药用于治疗拥有特定基因突变的早期乳腺癌患者。
| 交易日期 | 交易人 | 职位 | 类型 | 交易份额 | 价格 |
|---|---|---|---|---|---|
| 2016-10-13 | Auerbach (Alan H) | Chief Executive Officer | Buy | 150000 | -- |
| 2016-10-13 | Bryce (Richard Paul) | Officer | Buy | 31500 | -- |
| 2016-10-13 | Charnas (Robert) | Divisional Officer | Buy | 31500 | -- |
| 2016-10-13 | Eyler (Charles R) | Officer and Treasurer | Buy | 10500 | -- |
| 2016-10-13 | Lo (Steven) | Officer | Buy | 31500 | -- |
| 2015-07-05 | Bryce (Richard Paul) | Officer | Buy | 3000 | 11.30 |
| 2015-07-05 | Bryce (Richard Paul) | Officer | Sell | 3000 | 110.03 |
| 机构持股 | |||||
|---|---|---|---|---|---|
| 持有者 | 持有份额 | 持股比例 | 份额变化 | 变化率 | 报告日期 |
| Macquarie Investment Management | 772921 | 2.00% | 58501 | 8.19% | 2019-07-31 |
| Sarissa Capital Management LP | 1417000 | 3.67% | 74000 | 5.51% | 2019-03-31 |
| State Street Corporation | 1770445 | 4.59% | -1089165 | -38.09% | 2019-03-31 |
| Orbimed Advisors, LLC | 1880000 | 4.87% | -718883 | -27.66% | 2019-03-31 |
| HHG PLC | 2170423 | 5.62% | 308479 | 16.57% | 2019-03-31 |
| BlackRock Inc | 2503753 | 6.48% | -162133 | -6.08% | 2019-03-31 |
| Partner Fund Management LP | 2603920 | 6.74% | 2603920 | -- | 2019-03-31 |
| Vanguard Group Inc | 2946894 | 7.63% | 152157 | 5.44% | 2019-03-31 |
| SSGA Funds Management Inc | 4046371 | 10.48% | 78730 | 1.98% | 2019-07-31 |
| BlackRock Fund Advisors | 1375688 | 3.56% | 6457 | 0.47% | 2019-07-31 |
| Federated Investors Inc | 1297759 | 3.36% | -231141 | -15.12% | 2019-03-31 |
| Federated Equity Mgmt Co. Of Penn | 1297759 | 3.36% | -231141 | -15.12% | 2019-07-31 |
| T. Rowe Price Associates, Inc. | 785965 | 2.04% | 785965 | -- | 2019-03-31 |
| Delaware Management Company | 835536 | 2.16% | 21560 | 2.65% | 2019-07-31 |
| Great Point Partners LLC | 900000 | 2.33% | -479700 | -34.77% | 2019-03-31 |
| Macquarie Group Ltd | 987168 | 2.56% | 161972 | 19.63% | 2019-03-31 |
| Vanguard Investments Australia Ltd | 992792 | 2.57% | 57 | 0.01% | 2019-07-31 |
| Millennium Management LLC | 1078404 | 2.79% | -254292 | -19.08% | 2019-03-31 |
| Palo Alto Investors, LLC | 1180780 | 3.06% | 20880 | 1.80% | 2019-03-31 |
| Fred Alger Management Inc | 1190675 | 3.08% | 368634 | 44.84% | 2019-03-31 |
| Janus Capital Management LLC | 1998434 | 5.18% | -1723957 | -46.31% | 2019-06-30 |
| Camber Capital Management LLC | 1300000 | 3.38% | 550000 | 73.33% | 2018-12-31 |
| Melqart Asset Management (UK) Ltd. | 1159790 | 3.01% | 756490 | 187.58% | 2018-12-31 |
| FMR Inc | 860266 | 2.23% | -521627 | -37.75% | 2018-12-31 |
| Fidelity Management and Research Company | 855866 | 2.22% | -56887 | -6.23% | 2018-12-31 |
| Citadel Advisors Llc | 1124431 | 2.92% | 316423 | 39.16% | 2018-09-30 |
| Fidelity SelectCo, LLC | 867741 | 2.25% | -464587 | -34.87% | 2019-03-31 |
| Consonance Capital Management LP | 2303455 | 6.04% | 214338 | 10.26% | 2018-09-30 |
| venBio Select Advisor LLC | 1150685 | 3.02% | 116310 | 11.24% | 2018-09-30 |
| Point72 Asset Management, L.P. | 764590 | 2.00% | -155185 | -16.87% | 2018-09-30 |
| D. E. Shaw & Co LP | 792544 | 2.08% | -582501 | -42.36% | 2018-06-30 |
| BlackRock Institutional Trust Company NA | 870611 | 2.28% | 35001 | 4.19% | 2018-06-30 |
| Franklin Advisers, Inc. | 749845 | 1.97% | -106155 | -12.40% | 2018-06-30 |
| Franklin Resources Inc | 749845 | 1.97% | -106155 | -12.40% | 2018-06-30 |
| Redmile Group, LLC | 1095612 | 2.87% | 182039 | 19.93% | 2018-03-31 |
| Hartford Funds Management Company, LLC | 839855 | 2.20% | -259126 | -23.58% | 2018-10-31 |
| Jennison Associates LLC | 950998 | 2.49% | 465453 | 95.86% | 2018-06-30 |
| Orbimed Capital LLC | 1238846 | 3.30% | 1238846 | -- | 2017-12-31 |
| Schroder Investment Management North America Inc. | 7155648 | 5.65% | 6810683 | 1974.31% | 2018-06-30 |
| State Street Corp | 1971243 | 5.20% | 481475 | 32.32% | 2018-06-30 |
| Franklin Advisers Inc | 749845 | 1.98% | -106155 | -12.40% | 2018-06-30 |
| Close Finsbury Asset Management Limited | 818537 | 2.16% | -113680 | -12.19% | 2018-05-31 |
| Fidelity Institutional Asset Management | 706084 | 1.86% | 180005 | 34.22% | 2018-06-30 |
| Perceptive Advisors LLC | 442179 | 1.17% | -261641 | -37.17% | 2018-03-31 |
| Tourbillon Capital Partners LP | 421966 | 1.12% | 421966 | -- | 2018-03-31 |
| Rock Springs Capital Management LP | 475800 | 1.26% | 62900 | 15.23% | 2018-06-30 |
| Columbia Mangmt Investment Advisers, LLC | 409867 | 1.09% | 81971 | 25.00% | 2018-03-31 |
| NORGES BANK | 716003 | 1.90% | 323124 | 82.25% | 2017-12-31 |
| Polar Capital LLP | 445000 | 1.18% | 85000 | 23.61% | 2017-12-31 |
| Goldman, Sachs & Co. | 478372 | 1.27% | 4614 | 0.97% | 2017-12-31 |
| Adage Capital Partners Gp LLC | 2222500 | 5.91% | -327500 | -12.84% | 2017-12-31 |
| PointState Capital LP | 414010 | 1.11% | -191350 | -31.61% | 2017-09-30 |
| Emerald Advisers Inc | 402668 | 1.07% | 32633 | 8.82% | 2017-12-31 |
| Deutsche Bank AG | 597524 | 1.60% | 536025 | 871.60% | 2017-09-30 |
| Brookside Capital Management LLC | 657876 | 1.76% | 318882 | 94.07% | 2017-09-30 |
| Ascend Capital LLC | 716717 | 1.92% | 656662 | 1093.43% | 2017-09-30 |
| Wellington Management Company LLP | 702894 | 2.16% | 690271 | 5468.36% | 2016-09-30 |
| American Century Inv Mgt Inc | 651675 | 2.00% | 651675 | -- | 2016-09-30 |
| Northern Trust Investments N A | 275871 | 0.85% | 3176 | 1.16% | 2016-09-30 |
| Weatherbie M A & Co Inc | 262286 | 0.81% | -18699 | -6.65% | 2016-09-30 |
| Tekla Capital Management LLC | 260200 | 0.80% | -- | -- | 2016-09-30 |
| Bellevue Asset Management AG | 241991 | 0.75% | -190000 | -43.98% | 2016-09-30 |
| BB Biotech AG | 241991 | 0.74% | -190000 | -43.98% | 2016-09-30 |
| Clough Capital Partners, LP | 233100 | 0.72% | -13500 | -5.47% | 2016-09-30 |
| Capital Research Global Investors | 1944740 | 4.00% | 351181149 | 0.10% | 1999-11-30 |
| FMR LLC | 4035436 | 4.00% | 728719033 | 0.10% | 1999-11-30 |
| Alan. H. Auerbach | 4040000 | 4.00% | 729543200 | 0.10% | 1999-11-30 |
| Adage Capital Partners L.P | 5686668 | 4.00% | 1026898507 | 0.20% | 1999-11-30 |
| 共同基金持股 | |||||
|---|---|---|---|---|---|
| 持有者 | 持有份额 | 持股比例 | 份额变化 | 变化率 | 报告日期 |
| Pictet Biopharmaceutical Mother | 127600 | 0.33% | 64000 | 100.63% | 2019-04-15 |
| iShares Russell 2000 ETF | 671037 | 1.74% | 1309 | 0.20% | 2019-07-30 |
| Worldwide Healthcare | 706000 | 1.83% | -- | -- | 2019-04-30 |
| Delaware Sm-Cap Core Eq-UBS | 772921 | 2.00% | 58501 | 8.19% | 2019-06-30 |
| Delaware Small Cap Core Fund | 772921 | 2.00% | 21490 | 2.86% | 2019-06-30 |
| Federated Kaufmann Fund | 828159 | 2.14% | -171841 | -17.18% | 2019-03-31 |
| Vanguard Small Cap Index | 851517 | 2.21% | 4968 | 0.59% | 2019-06-30 |
| Vanguard Total Stock Market Index Fund | 986844 | 2.56% | 91 | 0.01% | 2019-06-30 |
| SPDR | 4018033 | 10.41% | 78812 | 2.00% | 2019-07-31 |
| Vanguard Small Cap Growth Index Fund | 484431 | 1.25% | 1711 | 0.35% | 2019-06-30 |
| Federated Kaufmann Small Cap Fund | 446600 | 1.16% | -54400 | -10.86% | 2019-03-31 |
| State Street Russell Small/Mid Cap | 128066 | 0.33% | -- | -- | 2019-06-30 |
| Fidelity | 144708 | 0.37% | -- | -- | 2019-06-30 |
| TIAA-CREF Quant Small-Cap Equity Fund | 145500 | 0.38% | -2300 | -1.56% | 2019-05-31 |
| Candriam Eqs L Biotechnology | 223200 | 0.58% | -- | -- | 2019-06-30 |
| iShares Russell 2000 Growth ETF | 278827 | 0.72% | -- | -- | 2019-07-30 |
| Alger SMid Cap Focus Fund | 364028 | 0.94% | 15111 | 4.33% | 2019-05-31 |
| iShares Nasdaq Biotechnology ETF | 384016 | 0.99% | 6517 | 1.73% | 2019-07-30 |
| Vanguard Extended Market Index Fund | 429209 | 1.11% | 2085 | 0.49% | 2019-06-30 |
| Pictet-Biotech | 188364 | 0.49% | -778 | -0.41% | 2018-09-30 |
| Janus Henderson Global Life Sciences Fd | 235084 | 0.61% | -- | -- | 2018-09-30 |
| Janus Henderson Venture Fund | 460612 | 1.19% | 74733 | 19.37% | 2019-03-31 |
| Janus Henderson Triton Fund | 1537822 | 3.98% | 224837 | 17.12% | 2019-03-31 |
| iShares US Small Cap ETF (CAD-Hedged) | 612630 | 1.59% | -1026 | -0.17% | 2019-05-30 |
| Vanguard Small Cap Index Fund | 848889 | 2.20% | 2376 | 0.28% | 2019-04-30 |
| Voya SmallCap Opportunities Fund | 189199 | 0.49% | 74848 | 65.45% | 2018-12-31 |
| Biotech Growth Trust Plc | 178000 | 0.46% | -58500 | -24.74% | 2018-11-30 |
| HBM Healthcare Investments AG | 205151 | 0.54% | -- | -- | 2018-09-30 |
| Polar Capital Healthcare Opps Fund | 197862 | 0.52% | -188267 | -48.76% | 2018-02-28 |
| Janus Henderson Research Fund | 914550 | 2.40% | -231148 | -20.18% | 2018-06-30 |
| Janus Henderson Enterprise Fund | 744613 | 1.95% | 53195 | 7.69% | 2018-03-31 |
| Carillon Eagle Small Cap Growth Fund | 207820 | 0.54% | -- | -- | 2018-06-30 |
| Franklin Biotechnology Discovery Fund | 263800 | 0.69% | -8500 | -3.12% | 2018-09-30 |
| T. Rowe Price New Horizons Fund | 597044 | 1.57% | -1264974 | -67.94% | 2017-12-31 |
| T. Rowe Price Health Sciences Fund | 634060 | 1.66% | -1488269 | -70.12% | 2017-12-31 |
| Hartford MidCap Fund | 806035 | 2.11% | -242906 | -23.16% | 2017-07-31 |
| Prudential Jennison Small Company B | 384820 | 1.02% | 52664 | 15.86% | 2018-07-31 |
| Emerald Growth A | 189099 | 0.50% | -- | -- | 2018-07-31 |
| Prudential Jennison Health Sciences A | 204643 | 0.54% | -- | -- | 2018-07-31 |
| Janus Research D | 914550 | 2.41% | -231148 | -20.18% | 2018-06-30 |
| Janus Triton D | 795067 | 2.10% | 129873 | 19.52% | 2018-06-30 |
| Vanguard Total Stock Mkt Idx | 798376 | 2.11% | 782 | 0.10% | 2018-07-31 |
| Janus Global Life Sciences D | 445773 | 1.18% | -64835 | -12.70% | 2018-06-30 |
| Vanguard Small Cap Growth Index Inv | 462544 | 1.22% | 8074 | 1.78% | 2018-07-31 |
| iShares Nasdaq Biotechnology | 429993 | 1.28% | -819 | -0.19% | 2018-09-12 |
| Vanguard Extended Market Idx Inv | 404392 | 1.07% | 3000 | 0.75% | 2018-07-31 |
| Delaware Small Cap Core A | 370900 | 0.98% | 24700 | 7.13% | 2018-07-31 |
| FIAM Small Company Pool | 157600 | 0.42% | 157600 | -- | 2018-03-31 |
| Fidelity Advisor | 226287 | 0.60% | -- | -- | 2018-07-31 |
| Eagle Small Cap Growth A | 207820 | 0.55% | -- | -- | 2018-06-30 |
| Franklin Biotechnology Discovery A | 282500 | 0.75% | -- | -- | 2018-07-31 |
| iShares Russell 2000 Growth | 280254 | 0.83% | -270 | -0.10% | 2018-09-12 |
| Janus Venture D | 242817 | 0.64% | -- | -- | 2018-06-30 |
| Janus Enterprise D | 744613 | 1.97% | 53195 | 7.69% | 2018-03-31 |
| State Street Russell Small/Mid Cap Idx Fd Cl I | 95621 | 0.26% | 5198 | 5.75% | 2017-06-30 |
| Fidelity Spartan | 132836 | 0.35% | -- | -- | 2018-04-30 |
| Wells Fargo Discovery Admin | 183100 | 0.48% | -- | -- | 2018-03-31 |
| T. Rowe Price Small-Cap Value | 222200 | 0.59% | -6700 | -2.93% | 2017-12-31 |
| T. Rowe Price New Horizons | 597044 | 1.59% | -1264974 | -67.94% | 2017-12-31 |
| T. Rowe Price Health Sciences | 634060 | 1.69% | -1488269 | -70.12% | 2017-12-31 |
| T. Rowe Price Health Sciences Port II | 122674 | 0.33% | 35243 | 40.31% | 2017-09-30 |
| VALIC Company I Health Sciences | 129101 | 0.35% | -7600 | -5.56% | 2017-10-31 |
| Hartford MidCap A | 1387087 | 3.77% | 12647 | 0.92% | 2016-12-31 |
| American Century Heritage Inv | 513944 | 1.40% | 147761 | 40.35% | 2016-12-31 |
| Hartford MidCap HLS IA | 356089 | 0.97% | -- | -- | 2016-12-31 |
| American Century All Cap Growth Inv | 117290 | 0.32% | 42090 | 55.97% | 2016-12-31 |
| Fidelity® Select Health Care Portfolio | 1228000 | 3.80% | -- | -- | 2015-09-30 |
| Fidelity® Select Biotechnology Portfolio | 1218897 | 3.80% | -- | -- | 2015-09-30 |
| Fidelity® OTC Portfolio | 946587 | 2.90% | -- | -- | 2015-09-30 |
| Franklin Biotechnology Discovery | 514000 | 1.60% | -15200 | -2.90% | 2015-07-31 |
| Fidelity Advisor® Health Care Fund | 342439 | 1.10% | -- | -- | 2015-09-30 |
| Fidelity Advisor® Biotechnology Fund | 296445 | 0.90% | -- | -- | 2015-09-30 |
| SPDR® S&P Biotech ETF | 229279 | 0.60% | 1500 | 0.70% | 2015-11-19 |
| VA CollegeAmerica Growth Fund of America | 1608000 | 5.00% | -- | -- | 2015-09-30 |
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